Prof. Henrik Jönsson
Sainsbury Laboratory Cambridge University

The focus of Henrik's research is to develop computational morphodynamics models at the cellular level describing multicellular tissues such as the shoot apical meristem. The models are developed in close collaboration with experimental groups and describe the dynamics of gene regulatory networks, hormone transport and signalling, cell growth and division, and mechanical properties. Integral for the research is the iterative evaluation of the models and their parameters to new experimental data, mainly in the form of live microscopy data.

This includes the development of  models for gene regulation and intercellular signalling, where the experimentally known CLAVATA-WUSCHEL negative feedback provides the core of the network. He develops models and optimises and evaluates model parameters with large perturbation experiments, where the approach focuses on regions of parameters to describe the model network behavior.

Jönsson Lab: https://www.slcu.cam.ac.uk/research/jonsson-group

Lab members

Postdoctoral Research-Associates

Dr Pau Formosa-Jordan
Dr Jérémy Gruel
Dr Benoit Landrein
Dr Ross Carter
Dr Pauline Durand

PhD students

Niklas Korsbo
Henrik Aahl
Filipa Lopes
Ioannis Tamvakis 

Selected recent publications

Landrein, B., Formosa-Jordan, P., Schuster, C., Melnyk, C.W., Yang, W., Turnbull, C., Meyerowitz, E.M., Locke, J., Jönsson, H. (2018) Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems through cytokinins. Proc Natl Acad Sci USA 115 (6) 1382-1387.

Mirabet, V, Krupinski, P, Hamant, O, Meyerowitz, EM, Jönsson, H, Boudaoud, A (2018) The self-organization of plant microtubules inside the cell volume yields their cortical localization, stable alignment, and sensitivity to external cues. PLoS Comp Biol 14 (2), e1006011.

Caggiano, M.P., Yu, X., Bhatia, N., Larsson, A., Ram, H., Ohno, C., Sappl, P., Meyerowitz, E.M., Jönsson, H., Heisler, M. (2017) Cell type boundaries organize plant development. eLife 6: e27421.

HM Meyer*, J Teles*, P Formosa-Jordan*, Y Refahi, R San-Bento, G Ingram, H Jönsson^, JCW Locke^, AHK Roeder^ (2017) Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal, eLife e19131. *joint first authors ^joint corresponding authors

Bhatia, N., Bozorg, B., Ohno, C., Jönsson, H., Heisler, M.G. (2016) Auxin acts through MONOPTEROS to regulate plant cell polarity and pattern phyllotaxis. Curr. Biol. 26, 3202-3208

L Willis*, Y Refahi*, R Wightman, B Landrein, J Teles, KC Huang, EM Meyerowitz, H Jönsson (2016) Cell size and growth regulation in the Arabidopsis thaliana apical stem cell niche
Proceedings of the National Academy of Sciences 113 (51), E8238-E8246. 

N Bhatia, B Bozorg, A Larsson, C Ohno, H Jönsson, MG Heisler (2016), 
Auxin acts through MONOPTEROS to regulate plant cell polarity and pattern phyllotaxis, Current Biology 26 (23), 3202-3208.

B Bozorg, P Krupinski, H Jönsson (2016) A continuous growth model for plant tissue, Physical Biology 13 (6), 065002.

BI Je, J Gruel, YK Lee, P Bommert, ED Arevalo, AL Eveland, Q Wu, A Goldshmidt, R Meeley, M Bartlett, M Komatsu, H Sakai, H Jönsson, D Jackson (2016), Signaling from maize organ primordia via FASCIATED EAR3 regulates stem cell proliferation and yield traits, Nature genetics 48 (7), 785-791.

J Gruel, B Landrein, P Tarr, C Schuster, Y Refahi, A Sampathkumar, O Hamant, EM Meyerowitz, H Jönsson (2016) An epidermis-driven mechanism positions and scales stem cell niches in plants, Science Advances 2, e1500989.

Review

S Braybrook, H Jönsson (2016) Shifting foundations: the mechanical cell wall and development Current Opinion in Plant Biology 29, 115-120