Jim Haseloff
Department of Plant Sciences

Jim's laboratory has established bioengineering standards, genomic tools and high throughput methods for work with the model plant system Marchantia polymorpha. These include high resolution microscopy methods that allow live visualisation of gene expression and cell dynamics. He is Cambridge Director of the OpenPlant Synthetic Biology Research Centre and Chair of the Synthetic Biology Strategic Research Initiative and founder of the Biomaker initiative

Twitter: @jimhaseloff

Haseloff lab: http://haseloff.plantsci.cam.ac.uk
OpenPlant: https://www.openplant.org
Biomaker: https://www.biomaker.org

University of Cambridge Synthetic Biology Strategic Research Initiative: http://synbio.cam.ac.uk

Lab members

Dr Susana Sauret-Gueto
Linda Silvestri
Mihails Delmans
Marius Rebmann
Marta Tomaselli
Dr Eftychios Frangedakis
Dr. Fernando Guzman-Chavez

Recent publications

Pollak B, Cerda A, Delmans M, Álamos S, Moyano T, West A, Gutiérrez RA, Patron N, Federici F and J Haseloff. Loop Assembly: a simple and open system for recursive fabrication of DNA circuits. New Phytologist, 222: 628-640, (2019).

Kan A, Del Valle I, Rudge T, Federici F, and J Haseloff, Intercellular adhesion promotes clonal mixing in growing bacterial populations. Royal Society Interface, 15 (146), (2018). 

Kahl L, Molloy J, Patron N, Matthewman C, Haseloff J, Grewal D, Johnson R and D Endy, Expanding options for material transfer via the OpenMTA. Nature Biotechnology, 36:923-927, (2018). 

Delmans M and J Haseloff, μCube: A framework for 3D printable optomechanics. Journal of Open Hardware. 2:1-9 (2018)

Yu Z, Boehm CR, Hibberd JM, Abell C, Haseloff J, Burgess JR and I Reyna-Llorens. Droplet-based microfluidic analysis and screening of single plant cells. bioRxiv, https://doi.org/10.1101/199992 (2017).

CR Boehm, PK Grant and J Haseloff. Programmed hierarchical patterning of bacterial populations. Nature Communications, 9: 776 doi:10.1038/s41467-018-03069-3 (2018).

Wintle BC, Boehm CR, Rhodes C, Molloy JC, Millett P, Adam L, Breitling R, Carlson R, Casagrande R, Dando M, Doubleday R, Drexler E, Edwards B, Ellis T, Evans NG, Hammond R, Haseloff J, Kahl L, Kuiken T, Lichman BR, Matthewman CA, Napier JA, ÓÉigeartaigh SS, Patron NJ, Perello E, Shapira P, Tait J, Takano E, Sutherland WJ. A transatlantic perspective on 20 emerging issues in biological engineering. eLife 6:e30247 DOI: 10.7554/eLife.30247

Bowman et al., Insights into Land Plant Evolution Garnered from the Marchantia polymorpha Genome. Cell, 171:287–304.

Christian R. Boehm, Bernardo Pollak, Nuri Purswani, Nicola Patron and Jim Haseloff, Synthetic Botany, Cold Spring Harbor Perspectives in Biology, doi: 10.1101/cshperspect.a023887.

Isaac N. Nuñez, Tamara F. Matute, Ilenne Del Valle, Anton Kan, Atri Choksi, Drew Endy, Jim Haseloff, Timothy Rudge, and Fernan Federici, Artificial symmetry-breaking for morphogenetic engineering bacterial colonies. ACS Synthetic Biology, 6:256–265 (2017).

Mihails Delmans, Bernardo Pollak and Jim Haseloff, MarpoDB: An open registry for Marchantia polymorpha genetic parts, Plant Cell Physiol. 58: e5(1–9).

Grant PK, Dalchau N, Brown JR, Federici F, Rudge TJ, Yordanov B, Patange O, Phillips A, Haseloff J. Orthogonal intercellular signaling for programmed spatial behavior. Molecular Systems Biology 12:849-861, (2016).

Boehm CR, Ueda M, Nishimura Y, Shikanai T, Haseloff J. A Cyan Fluorescent Reporter Expressed from the Chloroplast Genome of Marchantia polymorpha. Plant Cell Physiol. 57:291-9, (2016).

Rudge T, Brown J, Federici F, Dalchau N, Phillips A, Ajioka J, & Haseloff J. Characterization of intrinsic properties of promoters. ACS Synthetic Biology Jan 5:89-98, (2016).

Bowman JL, Araki T, Arteaga-Vazquez MA, Berger F, Dolan L, Haseloff J, Ishizaki K, Kyozuka J, Lin SS, Nagasaki H, Nakagami H, Nakajima K, Nakamura Y, Ohashi-Ito K, Sawa S, Shimamura M, Solano R, Tsukaya H, Ueda T, Watanabe Y, Yamato KT, Zachgo S, Kohchi T. The Naming of Names: Guidelines for Gene Nomenclature in Marchantia. Plant Cell Physiol. 57:257-61, (2016).

Patron NJ, (et al.) & Haseloff J. Standards for plant synthetic biology: a common syntax for exchange of DNA parts. New Phytologist 208:13-9, (2015).